https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2967 Wed 24 Jul 2013 22:50:59 AEST ]]> Characterizing Foxp3⁺ and Foxp3⁻ T cells in the homeostatic state and after allo-activation: resting CD4⁺Foxp3⁺ Tregs have molecular characteristics of activated T cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54659 Wed 10 Apr 2024 09:45:50 AEST ]]> An omnibus consistent adaptive percentile modified Wilcoxon rank sum test with applications in gene expression studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25652 Tue 26 Jun 2018 11:56:13 AEST ]]> Identification of differentially expressed gene using robust singular value decomposition https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29654 Thu 13 Jan 2022 10:28:43 AEDT ]]> Gene expression profile changes in Eisenia fetida chronically exposed to PFOA https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24675 Eisenia fetida is a terrestrial organism, which can be used to diagnose sub-lethal concentrations of PFOA by using molecular biomarkers. In order to identify potential molecular biomarkers, we have exposed E. fetida to 10 mg/kg of PFOA in soil for 8 months. The mRNA isolation, sequencing, transcriptome assembly followed by differential gene expression studies have revealed that genes that are involved in apoptotic process, reproduction, calcium signalling, neuronal development and lipid metabolism are predominantly affected. Highly specific genes that are altered by PFOA can be further validated and used as biomarker to detect sub-lethal concentrations of PFOA in the soil.]]> Sat 24 Mar 2018 07:10:52 AEDT ]]> Transcriptome analysis of Eisenia fetida chronically exposed to benzo(a)pyrene https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34310 Eisenia fetida is a sentinel organism in soil which can be used to diagnose the health of the soil. In order to identify potential molecular markers from Eisenia fetida to diagnose the presence of benzo(a) pyrene in soil, we exposed the organism to sub-lethal (10 mgKg-1) concentrations for a period of eight months and carried out transcriptome analysis. From the transcriptome, we have identified differentially expressed genes. Results showed that benzo(a)pyrene has altered the expression of calcium binding and calcium homeostasis, apoptotic process, cytoskeletal proteins, protein transport, nucleotide binding, lipid metabolism, peripheral neuronal development, cell division, wound healing and processing genes at transcription level. Several of the genes we reported here were not reported earlier. The highly up regulated and down regulated genes could be used as a molecular marker to diagnose the presence of benzo(a)pyrene in the soil.]]> Fri 01 Apr 2022 09:28:26 AEDT ]]>